2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR)

HMG-CoA Reductase (HMGCR)

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HMG-CoA Reductase (HMGCR) is the rate-limiting enzyme for cholesterol synthesis in the conversion of HMG-CoA to mevalonate. HMGCR is found in eukaryotes and prokaryotes. The phylogenetic analysis has revealed two classes of HMG-CoA reductase, the Class I enzymes of eukaryotes and some archaea and the Class II enzymes of eubacteria and certain other archaea.

Both in eukaryotes and in archaebacteria the enzyme HMGCR is known to catalyze an early reaction unique to isoprenoid biosynthesis. In humans, the HMG-CoA reductase reaction is rate-limiting for the biosynthesis of cholesterol and therefore constitutes a prime target of drugs that reduce serum cholesterol levels.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123672
    Lovastatin hydroxy acid sodium
    		Inhibitor 99.50%
    Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM.
    Lovastatin hydroxy acid sodium
  • HY-101873
    Atorvastatin lactone
    		Inhibitor
    Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
    Atorvastatin lactone
  • HY-104051
    Monacolin J
    		Inhibitor 98.97%
    Monacolin J is an inhibitor of cholesterol biosynthesis, and inhibits the activity of HMG-CoA reductase.
    Monacolin J
  • HY-125130
    Hesperetin 7-O-glucoside
    		Inhibitor 98.08%
    Hesperetin 7-O-glucoside is produced by the enzymatic conversion of Hesperidin. Hesperetin 7-O-glucoside is a potent human HMG-CoA reductase inhibitor and also effectively inhibits the growth of Helicobacter pylori. Antihypertensive effect.
    Hesperetin 7-O-glucoside
  • HY-13528
    Clinofibrate
    		Inhibitor 99.87%
    Clinofibrate (S-8527) is a hypelipidemic agent and a HMG-CoA reductase inhibitor.
    Clinofibrate
  • HY-17504BS
    Rosuvastatin-d3 sodium
    		Inhibitor 99.19%
    Rosuvastatin-d3 (sodium) is deuterium labeled Rosuvastatin.
    Rosuvastatin-d<sub>3</sub> sodium
  • HY-B0589S
    Atorvastatin-d5 hemicalcium
    		Inhibitor ≥98.0%
    Atorvastatin-d5 (hemicalcium) is the deuterium labeled Atorvastatin. Atorvastatin hemicalcium is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively[1][2][3].
    Atorvastatin-d<sub>5</sub> hemicalcium
  • HY-B0144BS
    Pitavastatin-d4 sodium
    		99.49%
    Pitavastatin-d4 (sodium) is deuterium labeled Pitavastatin (sodium).
    Pitavastatin-d<sub>4</sub> sodium
  • HY-17504R
    Rosuvastatin Calcium (Standard)
    		Inhibitor 99.94%
    Rosuvastatin (Calcium) (Standard) is the analytical standard of Rosuvastatin (Calcium). This product is intended for research and analytical applications. Rosuvastatin Calcium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Calcium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Calcium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Calcium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
    Rosuvastatin Calcium (Standard)
  • HY-B0165AR
    Pravastatin sodium (Standard)
    		Inhibitor 98.10%
    Pravastatin (sodium) (Standard) is the analytical standard of Pravastatin (sodium). This product is intended for research and analytical applications. Pravastatin sodium (CS-514 sodium) is an HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
    Pravastatin sodium (Standard)
  • HY-14664F
    (3R,5S)-Fluvastatin sodium
    		99.18%
    (3R,5S)-Fluvastatin ((3R,5S)-XU 62-320) sodium is the 3R,5S-isomer Fluvastatin. Fluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. Fluvastatin protects vascular smooth muscle cells against oxidative stress through the Nrf2-dependent antioxidant pathway.
    (3R,5S)-Fluvastatin sodium
  • HY-114316
    HMG499
    		Inhibitor
    HMG499 is a potent and selective HMG-CoA reductase inhibitor with an IC50 of 0.41 μM. HMG499 can prevent statins-induced accumulation of HMGCR, reduce serum cholesterol levels and decrease atherosclerosis.
    HMG499
  • HY-106281
    Bemfivastatin
    		Inhibitor 99.48%
    Bemfivastatin (PPD 10558) is an orally active, HMG-CoA Reductase (HMGCR) inhibitor, also known as Statin. Bemfivastatin enhances the activity of liver extraction. Bemfivastatin exhibits little developmental toxicity effects in pregnant rats and rabbits via daily oral doses during organogenesis period. The no observed adverse effect level (NOAEL) are ≥320 mg/kg/day for rats developmental toxicity, 12.5 mg/kg/day for rabbits maternal toxicity, and 25 mg/kg/day for rabbits developmental toxicity, respectively. Bemfivastatin can be used for research on Statin-related hypercholesterolemic myalgia with inability to tolerate statins.
    Bemfivastatin
  • HY-122439
    Lovastatin acid
    		Inhibitor
    Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM.
    Lovastatin acid
  • HY-B0144AS1
    Pitavastatin-d5 sodium
    		Inhibitor
    Pitavastatin-d5 (sodium) is the deuterium labeled Pitavastatin sodium. Pitavastatin (NK-104) is a potent hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor. Pitavastatin inhibits cholesterol synthesis from acetic acid with an IC50 of 5.8 nM in HepG2 cells. Pitavastatin is an efficient hepatocyte low-density lipoprotein-cholesterol (LDL-C) receptor inducer. Anti-cancer activity.
    Pitavastatin-d<sub>5</sub> sodium
  • HY-B0144AS
    Pitavastatin-d4
    		Inhibitor 99.09%
    Pitavastatin-d4 is deuterium labeled Pitavastatin. Pitavastatin is a potent HMG-CoA reductase inhibitor.
    Pitavastatin-d<sub>4</sub>
  • HY-17504S
    Rosuvastatin-d6 calcium
    		Inhibitor 98.54%
    Rosuvastatin-d6 (calcium) is deuterium labeled Rosuvastatin.
    Rosuvastatin-d<sub>6</sub> calcium
  • HY-N2923
    β-Amyrin acetate
    		Inhibitor 99.47%
    β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase.
    β-Amyrin acetate
  • HY-B0165
    Pravastatin
    		Inhibitor
    Pravastatin (CS-514) is a competitive HMG-CoA reductase inhibitor against sterol synthesis with IC50 of 5.6 μM.
    Pravastatin
  • HY-B0589E
    Atorvastatin hemicalcium trihydrate
    		Inhibitor
    Atorvastatin hemicalcium trihydrate is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium trihydrate inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    Atorvastatin hemicalcium trihydrate
Cat. No. Product Name / Synonyms Application Reactivity